熊本大学大学院生命科学研究部 神経精神医学分野:神経精神科

研究業績

1996〜2000年の研究業績

原著論文

1996年(平成8年)
1.Kimura T, Takamatsu J, Ikeda K, Kondo A, Miyakawa T, Horiuchi S. Accumulation of advanced glycation end products of the Maillard reaction with age in human hippocampal neurons. Neurosci Lett 208: 53-56, 1996.

2.Kimura T, Ono T, Takamatsu J, Yamamoto H, Ikegami K, Kondo A, Hasegawa M, Ihara Y, Miyamoto E, Miyakawa T. Sequential changes of tau-site-specific phosphorylation during development of paired helical filaments. Dementia 7: 177-181, 1996.

3.Kimura T, Ikeda K, Takamatsu J, Miyata T, Sobue G, Miyakawa T, Horiuchi S. Identification of advanced glycation end products of the Maillard reaction in Pick's disease. Neurosci Lett 219: 95-98, 1996.

4.Kimura T, Horiuchi S. Ne-carboxymethyllysine and neurofibrillary tangles. Neurosci Lett 217: 209, 1996.

5.木村武実, 高松淳一. AGEと老年性疾患:主としてアルツハイマー病. Bio Clinica 11: 331-334, 1996.

6.木村武実, 向山恵子, 高松淳一, 弟子丸元紀, 有働信昭, 中村敬二, 福光弘明. 精神分裂病における自律神経機能:laser Doppler flowmetryによる定量的分析. 精神医学 38: 871-873, 1996.

7.Fujise N, Hori N, Kosaka T. Calretinin immunoreactive mossy cells in the hilus of the mouse dentate gyrus. Soc Neurosci Abst 22: 902, 1996.

8.Ikegami K, Kimura T, Katsuragi S, Ono T, Yamamoto H, Miyamoto E, Miyakawa, T. Immunohistochemical examination of phosphorylated tau in granulovacolar degeneration granules. Psychiatr Clin Neurosci 50: 137-140, 1996.

9.Nakashima H, Ueda K, Yasugawa S, Katsuragi S, Kimura T, Miyakawa T. Erythrocyte deformability in schizophrenic patients. Psychiatr Clin Neurosci. 50: 191-194, 1996.

10.中島 央, 安川節子, 中林 潤, 上田啓司, 高松淳一, 宮川太平. 精神分裂病患者赤血球における膜リン脂質に関する研究. 神経化学35: 242-243, 1996.

11.Kondo A, Baba S, Iwaki T, Harai H, Koga H, Kimura T, Takamatsu T. Hyperbaric oxygenation prevents delayed neuronal death following transient ischaemia in the gerbil hippocampus. Neuropathol Appl Neurobiol 22: 350-360, 1996.

12.Tashima K, Yamamoto H, Setoyama C, Ono T, Miyamoto E. Overexpression of Ca2+/calmodulin-dependent protein kinase II inhibits neurite outgrowth of PC12 cells. J Neurochem 66: 57-64, 1996.

13.Liu Y, Fujise N, Kosaka T. Distribution of calretinin immunoreactivity in the mouse dentate gyrus: I. general description. Exp Brain Res 108: 389-403, 1996.


1997年(平成9年)
1.Miyakawa T, Katsuragi S, Higuchi Y, Yamashita K, Kimura T, Teraoka K, Ono T, Ishizuka K. Changes of Microvessels in the Brain with Alzheimer's Disease. Annals New York Academy of Science 826 428-432, 1997

2. Takamatsu J, Kimura T, Kondo A, Iwatsubo T. Subpial amyloid plaques in the cerebellum in a case of Alzhiemer's disease. Dement. Geriatr Cogn Disord 8: 157-162, 1997.

3.本島昭洋, 井形朋英, 下地明友, 杉村 謙. 電撃療法により短期間に寛解した妄想型うつ病の一例. 精神科治療 12: 935-941, 1997.

4.Kimura T, Yokota S, Igata-Yi R, Shono M, Takamatsu J, Miyakawa T. Apolipoprotein E e2 allele and early onset schizophrenia. Neurosci Lett 231: 53-55, 1997.

5.Kimura T, Yokota S, Shono M, Igata-Yi R, Takamatsu J, Miyakawa T. Apolipoprotein E e4 allele and schizophrenia. Neuroreport 8: R1-2, 1997.

6.木村武実, 宮川太平, 堀内正公. アルツハイマー病とAGE. Bio Clinica 12: 539-542, 1997.

7.坂西信彦, 野澤和由, 下地明友, 宮川太平. 多量飲酒・ヘロイン乱用後に白質脳症を呈した1例. 精神医学 39: 647-649, 1997.

8.Igata-Yi R, Igata T, Ishizuka K, Kimura T, Sakamoto S, Katsuragi S, Takamatsu J, Miyakawa T. Apolipoprotein E genotype and psychosis. Biol Psychiatry 41: 906-908, 1997.

9.Nakamura T, Ogawa H. Neural interaction between cortical taste neurons in rats: a cross-correlation analysis. Chem Sen 22: 517-528, 1997.

10.Ishizuka K, Kimura T, Igata-Yi R, Katsuragi S, Takamatsu J, Miyakawa T. Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease. Psychiatry Clin Neurosci 51: 135-138, 1997.

11.Ishizuka K, Igata-Yi R, Kimura T, Hieshima K, Kukita T, Kin Y, Misumi Y, Yamamoto M, Nomiyama H, Miura R, Takamatsu J, Katsuragi S, Miyakawa T. Expression and distribution of CC chemokine macrophage inflammatory protein-1a/LD78 in the human brain. Neuroreport 8: 1215-1218, 1997.

12.Hieshima K, Imai T, Baba M, Shoudai K, Ishizuka K, Nakagawa T, Tsuruta J, Takeya M, Sakaki Y, Takatsuki K, Miura R, Opdnakker G, Van Damme J, Yoshie O, Nomiyama, H. A novel human CC chemokine PARK that is most homologous to macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes. J Immunology 159: 1140-1149, 1997.


1998年(平成10年)
1.Shimoji A, Eguchi S, Ishizuka K, Cho T, Miyakawa T. Mediation between the shamanistic model and the psychiatric model in a shamanistic climate: a viewpoint of medical anthropology. Psychiatry Clin Neurosci 52, 581-586. 1998.

2.下地明友. 物語生成, 間物語性, 臨床の零度. 文化のこころ 2: 46-50. 1998.

3.Takamatsu J, Kondo A, Ikegami K, Kimura T, Fujii H, Mitsuyama Y, Hashizume Y. Selective expression of Ser 199/202 phosphorylated tau in a case of frontotemporal dementia. Dement Geriatr Cogn Disord 9: 82-89, 1998.

4.Kimura T, Takamatsu J, Miyata T, Miyakawa T, Horiuchi S. Localization of advanced glycation end product structures, Ne-(carboxymethyl)lysine and pentosidine, in age-related inclusions in human brains. Pathol Int 48: 575-579, 1998.

5.井形るり子, 石塚公子, 井形朋英, 花輪昭太郎, 木村武実, 本田雅博, 庄野昌博, 宮川太平. アポリポ蛋白Eの遺伝子多型と初老期老年期の精神疾患. 九州神経精神医学44: 175-178, 1998.

6.Fujise N, Liu Y, Hori N, Kosaka T. Distribution of calretinin immunoreactivity in the mouse dentate gyrus: II. mossy cells, with special reference to their dorsoventral difference in calretinin immunoreactivity. Neuroscience 82: 181-200, 1998.

7.Futatsuka M, Maeda S, Inada T, Nagano M, Shono M, Miyakita T. Whole-body vibration and health effects in the agricultural machinery drivers. Industrial Health 36: 127-132, 1998.

8.Futatuka M, Kitano T, Shono M, Fukuda Y, Wakamiya J, Ikegami M, Osame M, Arimura K, Nakagawa M. Assessment of the biological age of the population living in a methylmercury polluted area. Environ Sci 6: 11-19, 1998.

9.Koga H, Kondo A, Kimura T, Takamatsu J. Familial multiple system degeneration associated with iron deposition: determination of subcellular localization of elementary iron by energy-dispersive X-ray analysis. Clin Neuropathol 17: 35-40, 1998.

10.Hirai S, Shin Y, Kageshita T, Syono M, Maekawa Y, Ono T. Clinical course of atopic dermatitis in Japanese patients. J Dermatol Sci 18: 128-131, 1998.


1999年(平成11年)
1.下地明友. 薬物性脳症状群:特に向精神薬による「軽い意識障害」と「パラドックス反応」などの中枢神経障害について. 医薬ジャーナル 35: 113-117. 1999.

2.Fujise N, Kosaka T. Mossy cells in the mouse dentate gyrus: identification in the dorsal hilus and their distribution along the dorsoventral axis. Brain Res 816: 500-511, 1999.

3.Takeuchi Y, Yamamoto H, Matsumoto K, Kimura T, Katsuragi S, Miyakawa T, Miyamoto E. Nuclear localization of the gamma subunit of Ca2+/calmodulin-dependent protein kinase II in rat cerebellar granule cells. J Neurochem 72: 815-825, 1999.

4.Masahiro Honda, Tadashi Kaname, Ruriko Igata-Yi, Tomohide Igata, Yasuyuki Hitoshi, Koji Ogomori, Taihei Miyakawa, and Ken-ichi Yamamura.Novel intronic polymorphisms in the presenilin-2 gene and a case-control association study of Alzheimer's disease. Psychiatry and Clinical Neurosciences 53: 579-585,1999.


2000年(平成12年)
1.Miyakawa T, Kimura T, Hirata S, Fujise N, Ono T, Ishizuka K, Nakabayashi J. Role of blood vessels in producing pathological changes in the brain with Alzheimer's disease. Ann NY Acad Sci 903: 46-54, 2000.

2.弟子丸元紀, 池上 研, 下原宣彦, 荒木祐子. 同胞発症の「若年周期精神病」児の経過(11年)と治療:治療面での反省と状態像の変遷. 児童青年期精神医学, 41: 106, 2000.

3.Shimoji A, Miyakawa T. Culture-bound syndrome and the culturally sensitive approach: from a viewpoint of medical anthropology. Psychiatry Clin Neurosci 54: 461-466, 2000.

4.Kimura T, Yamamoto H, Takamatsu J, Yuzuriha T, Miyamoto E, Miyakawa T. Phosphorylation of MARCKS in Alzheimer disease brains. Neuroreport 11: 869-873, 2000.

5.Kimura T, Shono M, Yokota S, Igata-Yi R, Takamatsu J, Miyakawa T. Apolipoprotein E e3 allele is not a risk factor of schizophrenia: a study of 314 Japanese patients. Neuropsychobiology 42: 66-68, 2000.

6.Kimura T, Shono M, Yokota S, Ishizuka K, Watanabe M, Takamatsu J, Miyakawa T. Apolipoprotein E e4 and tardive dyskinesia in a Japanese population. J Psychiat Res 34: 329-332, 2000.

7.木村武実, 城野 匡, 宮川太平, 堀内正公. Advanced glycation end products (AGE) とアルツハイマー病. 脳の科学 22 (2000年増刊号): 145-148, 2000.

8.Takeuchi Y, Yamamoto H, Miyakawa T, Miyamoto E. Increase of Brain-Derived Neurotrophic Factor Gene Expression in NG108-15 Cells by Nuclear Isoforms of Ca2+/calmodulin-Dependent Protein Kinase II. J Neurochem 74: 1913-1922, 2000.

9.Takeuchi Y, Yamamoto H, Fukunaga K, Miyakawa T, Miyamoto E. Identification of the isoforms of Ca2+/calmodulin-dependent protein kinase II in rat astrocytes and their subcellular lacalization. J Neurochem 74: 2557-2567, 2000.

10.Uesugi N, Sakata N, Nagai R, Jono T, Horiuchi S, Takebayashi S. Glycoxidative modification of AA amyloid deposits in renal tissue. Nephrol Dial Transplant 15: 355-365, 2000.

著書

1996年(平成8年)
1.Kosaka T, Fukuda T, Fujise N. Aika Y. Cellular organization of the hippocampal formation. In Integrative and Molecular Approach to Brain Function: International Congress Series 1116 (eds. Ito M, Miyashita Y). Elsevier, Amsterdam, pp. 181-191, 1996.


1997年(平成9年)
1.木村武実, 堀内正公. 神経変性疾患と蛋白糖化反応:アルツハイマー病. 蛋白の糖化:AGEの基礎と臨床(繁田幸男, 谷口直之編). 医学書院, 東京, pp.104-108, 1997.


1998年(平成10年)
1.下地明友. 風土的視点と精神科臨床:「臨床場」の問題. 臨床精神医学講座第23巻「多文化間精神医学」(高畑直彦、三田俊夫編). 中山書店, 東京, pp.377-390, 1998.

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私たち熊本大学神経精神科は、社会問題にもなっている認知症、最近の自殺の増加で注目をされているうつ病、自閉症を中心とする発達障害、新しい薬物療法と生活支援により社会復帰が主要な治療目標となった統合失調症、などを取り扱う精神科医療専門の診療科です。当科では、バランス感覚のとれた優秀な若手精神科医の育成を目指しています。県内外の関連病院の全面的な協力のもと、様々な精神科医療の現場を経験できる研修システムを構築しています。研究に関しては、様々な場所で臨床ならびに研究のキャリアを積んだ教官のもと、若い先生方の研究意欲にも幅広く対応できます。